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KMID : 0191120010160010069
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Journal of Korean Medical Science
2001 Volume.16 No. 1 p.69 ~ p.74
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Combination of Oxaliplatin, Fluorouracil, and Leucovorin in the Treatment of Fluoropyrimidine-Pretreated Patients with Metastatic Colorectal Cancer
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Jung-Hee Lee
Je-Hwan Lee/Tae-Won Kim/Kyoo-Hyung Lee/Yoon-Koo Kang/Jung-Shin Lee/Sang-Hee Kim/Hee Cheol Kim/Chang Sik Yu/Jin Cheon Kim/Woo-Kun Kim
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Abstract
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There has been no standard therapy for patients with metastatic colorectal cancer who have failed to first-line fluorouracil-based treatment. The present study was designed to assess the efficacy and toxicities of a combination of oxaliplatin, 5-fluorouracil (5-FU) and leucovorin in fluoropyrimidine-pretreated patients with metastatic colorectal cancer. Chemotherapy consisted of oxaliplatin 85 mg/m2 on day 1, followed by leucovorin 20 mg/m2 and 5-FU 1,200 mg/m2 on days 1 and 2. Treatment courses were repeated every two weeks. Thirty-nine patients were enrolled in this study. All patients previously received fluoropyrimidine-based chemotherapy. Thirty-one patients were assessable for response and 33 for treatment toxicity. Six patients required dose reduction of 5-FU due to grade III/IV cytopenia. Nausea/vomiting and peripheral neuropathy were common non-hematologic toxicities. Overall response rate was 42.0% including 3 complete response and 10 partial response. The median response duration was 91 days (range, 28-224+). The median duration of progression-free survival was 132 days (range, 40-308). A combination of oxaliplatin, 5-FU, and leucovorin showed high response rate in fluoropyrimidine-pretreated patients with metastatic colorectal cancer, but the duration of response was relatively short. It may be worthwhile to explore its therapeutic potential in the first-line treatment setting.
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